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{Influence of the corticospinal tract wiring pattern on sensorimotor functional connectivity and clinical correlates of upper limb function in unilateral cerebral palsy}
Type of publication: Article
Citation: Simon-Martinez2019
Journal: Scientific Reports
Volume: 9
Number: 1
Year: 2019
Month: dec
Pages: 8230
Publisher: Nature Publishing Group
ISSN: 20452322
URL: http://www.nature.com/articles...
DOI: 10.1038/s41598-019-44728-9
Abstract: In children with unilateral cerebral palsy (uCP), the corticospinal tract (CST)-wiring patterns may differ (contralateral, ipsilateral or bilateral), partially determining motor deficits. However, the impact of such CST-wiring on functional connectivity remains unknown. Here, we explored resting-state sensorimotor functional connectivity in 26 uCP with periventricular white matter lesions (mean age (standard deviation): 12.87 m (±4.5), CST wiring: 9 contralateral, 9 ipsilateral, 6 bilateral) compared to 60 healthy controls (mean age (standard deviation): 14.54 (±4.8)), and between CST-wiring patterns. Functional connectivity from each M1 to three bilateral sensorimotor regions of interest (primary sensory cortex, dorsal and ventral premotor cortex) and the supplementary motor area was compared between groups (controls vs. uCP; and controls vs. each CST-wiring group). Seed-to-voxel analyses from bilateral M1 were compared between groups. Additionally, relations with upper limb motor deficits were explored. Aberrant sensorimotor functional connectivity seemed to be CST-dependent rather than specific from all the uCP population: in the dominant hemisphere, the contralateral CST group showed increased connectivity between M1 and premotor cortices, whereas the bilateral CST group showed higher connectivity between M1 and somatosensory association areas. These results suggest that functional connectivity of the sensorimotor network is CST-wiring-dependent, although the impact on upper limb function remains unclear.
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Keywords: Neonatal brain damage, Paediatric research
Authors Simon-Martinez, Cristina
Jaspers, Ellen
Alaerts, Kaat
Ortibus, Els
Balsters, Joshua
Mailleux, Lisa
Blommaert, Jeroen
Sleurs, Charlotte
Klingels, Katrijn
Amant, Frédéric
Uyttebroeck, Anne
Wenderoth, Nicole
Feys, Hilde
Added by: []
Total mark: 0
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