TY  - JOUR
ID  - Simon-Martinez2019
T1  - {Influence of the corticospinal tract wiring pattern on sensorimotor functional connectivity and clinical correlates of upper limb function in unilateral cerebral palsy}
A1  - Simon-Martinez, Cristina
A1  - Jaspers, Ellen
A1  - Alaerts, Kaat
A1  - Ortibus, Els
A1  - Balsters, Joshua
A1  - Mailleux, Lisa
A1  - Blommaert, Jeroen
A1  - Sleurs, Charlotte
A1  - Klingels, Katrijn
A1  - Amant, Frédéric
A1  - Uyttebroeck, Anne
A1  - Wenderoth, Nicole
A1  - Feys, Hilde
JA  - Scientific Reports
Y1  - 2019
VL  - 9
IS  - 1
SP  - 8230
PB  - Nature Publishing Group
SN  - 20452322
UR  - http://www.nature.com/articles/s41598-019-44728-9
M2  - doi: 10.1038/s41598-019-44728-9
KW  - Neonatal brain damage
KW  - Paediatric research
N2  - In children with unilateral cerebral palsy (uCP), the corticospinal tract (CST)-wiring patterns may differ (contralateral, ipsilateral or bilateral), partially determining motor deficits. However, the impact of such CST-wiring on functional connectivity remains unknown. Here, we explored resting-state sensorimotor functional connectivity in 26 uCP with periventricular white matter lesions (mean age (standard deviation): 12.87 m (±4.5), CST wiring: 9 contralateral, 9 ipsilateral, 6 bilateral) compared to 60 healthy controls (mean age (standard deviation): 14.54 (±4.8)), and between CST-wiring patterns. Functional connectivity from each M1 to three bilateral sensorimotor regions of interest (primary sensory cortex, dorsal and ventral premotor cortex) and the supplementary motor area was compared between groups (controls vs. uCP; and controls vs. each CST-wiring group). Seed-to-voxel analyses from bilateral M1 were compared between groups. Additionally, relations with upper limb motor deficits were explored. Aberrant sensorimotor functional connectivity seemed to be CST-dependent rather than specific from all the uCP population: in the dominant hemisphere, the contralateral CST group showed increased connectivity between M1 and premotor cortices, whereas the bilateral CST group showed higher connectivity between M1 and somatosensory association areas. These results suggest that functional connectivity of the sensorimotor network is CST-wiring-dependent, although the impact on upper limb function remains unclear.
M1  - file={:C$\backslash$:/Users/cristina.simonmar/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Simon-Martinez et al. - 2019 - Influence of the corticospinal tract wiring pattern on sensorimotor functional connectivity and clinical.pdf:pdf}
ER  -