Automated segmentation of pediatric neuroblastoma on multi-modal MRI: Results of the SPPIN challenge at MICCAI 2023, MDPI Bioengineering, 2025
| Tipo de publicação: | Artigo |
| Citação: | |
| Publication status: | Published |
| Journal: | MDPI Bioengineering, nov. 25 |
| Ano: | 2025 |
| Mês: | November |
| DOI: | https://doi.org/10.3390/bioengineering12111157 |
| Resumo: | Introduction: Surgery plays an important role within the treatment for neuroblastoma, a common pediatric cancer. This requires careful planning, often via magnetic resonance imaging (MRI)-based anatomical 3D models. However, creating these models is often timeconsuming and user dependent. We organized the Surgical Planning in PedIatric Neuroblastoma (SPPIN) challenge, to stimulate developments on this topic, and set a benchmark for fully automatic segmentation of neuroblastoma on multi-model MRI. Methods: The challenge started with a training phase, where teams received 78 sets of MRI scans from 34 patients, consisting of both diagnostic and post-chemotherapy MRI scans. Then, in the preliminary test phase, the team algorithms could be tested on 7 scans belonging to 3 patients. The final test phase, consisting of 18 MRI sets from 9 patients, determined the ranking of the teams. Ranking was based on the Dice similarity coefficient (Dice score), the 95th percentile of the Hausdorff distance (HD95) and the volumetric similarity (VS). The SPPIN challenge was hosted at MICCAI 2023 as a one-time event. Results: The final leaderboard consisted of 9 teams. The highest-ranking team achieved a median Dice score 0.82, a median HD95 of 7.69 mm and a VS of 0.91, utilizing a large, pretrained network called STU-Net. A significant difference for the segmentation results between diagnostic and post-chemotherapy MRI scans was observed (Dice = 0.89 vs Dice = 0.59, P = 0.01) for the highest-ranking team. Conclusion: SPPIN is the first medical segmentation challenge in extracranial pediatric oncology. The highest-ranking team used a large pre-trained network, suggesting that pretraining can be of use in small, heterogenous datasets. Although the results of the highestranking team were high for most patients, segmentation especially in small, pre-treated tumors was insufficient. Therefore, more reliable segmentation methods are needed to create clinically applicable models to aid surgical planning in pediatric neuroblastoma. |
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| Adicionado por: | [] |
| Total mark: | 0 |
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