{Structural Brain Damage and Upper Limb Kinematics in Children with Unilateral Cerebral Palsy.}
| Publicatietype: | Artikel |
| Citatie: | Mailleux2017c |
| Tijdschrift: | Frontiers in human neuroscience |
| Deel: | 11 |
| Jaar: | 2017 |
| Pagina's: | 607 |
| ISSN: | 1662-5161 |
| URL: | http://journal.frontiersin.org... |
| DOI: | 10.3389/fnhum.2017.00607 |
| Samenvatting: | {Background: In children with unilateral cerebral palsy (uCP) virtually nothing is known on the relation between structural brain damage and upper limb (UL) kinematics quantified with three-dimensional movement analysis (3DMA). This explorative study aimed to (1) investigate differences in UL kinematics between children with different lesion timings, i.e., periventricular white matter (PWM) vs. cortical and deep gray matter (CDGM) lesions and (2) to explore the relation between UL kinematics and lesion location and extent within each lesion timing group. Methods: Forty-eight children (age 10.4 ± 2.7 year; 29 boys; 21 right-sided; 33 PWM; 15 CDGM) underwent an UL 3DMA during a reach-to-grasp task. Spatiotemporal parameters [movement duration, (timing of) maximum velocity, trajectory straightness], the Arm Profile Score (APS) and Arm Variable Scores (AVS) were extracted. The APS and AVS refer to the total amount of movement pathology and movement deviations of the wrist, elbow, shoulder, scapula and trunk respectively. Brain lesion location and extent were scored based on FLAIR-images using a semi-quantitative MRI-scale. Results: Children with CDGM lesions showed more aberrant spatiotemporal parameters (p {\textless} 0.03) and more movement pathology (APS |
| Gebruikersvelden: | p={0.04) as the strongest predictors, explaining 34{\%} of the variance in aps. conclusion: ul kinematic deviations are more influenced by lesion location and extent in children with later (cdgm) versus earlier lesions (pwm), except for proximal movement pathology. damage to the plic is a significant predictor for ul movement pathology irrespective of lesion timing.}}, file={:C$\backslash$:/Users/cristina.simonmar/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Mailleux et al. - 2017 - Structural Brain Damage and Upper Limb Kinematics in Children with Unilateral Cerebral Palsy.pdf:pdf}, pmid={29311871}, |
| Trefwoorden: | biomechanical phenomena, Brain injuries, cerebral palsy, Magnetic resonance imaging, Upper extremity |
| Auteurs | |
| Toegevoegd door: | [] |
| Totaalscore: | 0 |
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