Dear guest, welcome to this publication database. As an anonymous user, you will probably not have edit rights. Also, the collapse status of the topic tree will not be persistent. If you like to have these and other options enabled, you might ask Admin (Ivan Eggel) for a login account.
 [BibTeX] [RIS]
White matter characteristics of motor, sensory and interhemispheric tracts underlying impaired upper limb function in children with unilateral cerebral palsy
Type of publication: Article
Citation:
Journal: Brain Structure and Function
Volume: 225
Year: 2020
Pages: 1495-1509
DOI: https://doi.org/10.1007/s00429-020-02070-1
Abstract: This study explored the role of lesion timing (periventricular white matter versus cortical and deep grey matter lesions) and type of corticospinal tract (CST) wiring pattern (contralateral, bilateral, ipsilateral) on white matter characteristics of the CST, medial lemniscus, superior thalamic radiations and sensorimotor transcallosal fibers in children with unilateral cerebral palsy (CP), and examined the association with upper limb function. Thirty-four children (mean age 10 years 7 months ± 2 years 3 months) with unilateral CP underwent a comprehensive upper limb evaluation and diffusion weighted imaging (75 directions, b value 2800). Streamline count, fractional anisotropy and mean diffusivity were extracted from the targeted tracts and asymmetry indices were additionally calculated. Transcranial magnetic stimulation was applied to assess the CST wiring pattern. Results showed a more damaged CST in children with cortical and deep grey matter lesions (N = 10) and ipsilateral CST projections (N = 11) compared to children with periventricular white matter lesions (N = 24; p < 0.02) and contralateral CST projections (N = 9; p < 0.025), respectively. Moderate to high correlations were found between diffusion metrics of the targeted tracts and upper limb function (r = 0.45–0.72; p < 0.01). Asymmetry indices of the CST and sensory tracts could best explain bimanual performance (74%, p < 0.0001) and unimanual capacity (50%, p = 0.004). Adding lesion timing and CST wiring pattern did not further improve the model of bimanual performance, while for unimanual capacity lesion timing was additionally retained (58%, p = 0.0002). These results contribute to a better understanding of the underlying neuropathology of upper limb function in children with unilateral CP and point towards a clinical potential of tractography.
Keywords: Brain injuries, Diffusion magnetic resonance imaging, Transcranial magnetic stimulation, Unilateral cerebral palsy, Upper extremity
Authors Mailleux, Lisa
Simon-Martinez, Cristina
Radwan, Ahmed
Blommaert, Jeroen
Gooijers, Jolien
Wenderoth, Nicole
Klingels, Katrijn
Ortibus, Els
Sunaert, Stefan
Feys, Hilde
Added by: []
Total mark: 0
Attachments
  • Mailleux2020_Article_WhiteMatt...
Notes
    Topics