TY - JOUR ID - In recent years, several algorithms have been developed for the segmentation of the Inferior Alveolar Canal (IAC) in Cone-Beam Computed Tomography (CBCT) scans. However, the availability of public datasets in this domain is limited, resulting in a lack of T1 - Segmenting the Inferior Alveolar Canal in CBCTs Volumes: The ToothFairy Challenge A1 - Bolelli, Federico A1 - Lumetti, Luca A1 - Wang, Lisheng A1 - Wodzinski, Marek A1 - Müller, Henning A1 - Maier-Hain, Klaus A1 - Ginneken, Bram van A1 - Grana, Costantino JA - IEEE Transactions on Medical Imaging Y1 - 2025 VL - Volume 44, Issue : 4, Arpil 2025 SP - 1890 EP - 1906 SN - https://pubmed.ncbi.nlm.nih.gov/ UR - https://ieeexplore.ieee.org/document/10816445 M2 - doi: https://doi.org/10.1109/TMI.2024.3523096 KW - 3D Network KW - 3D U-Net Author Keywords Segmentation KW - algorithms KW - Annotation Process KW - Annotations KW - Benchmark testing KW - Challenge Participants KW - Common Benchmark KW - computed tomography MeSH Terms Cone-Beam Computed Tomography KW - Cone-beam Computed Tomography Images KW - Cone-beam Computed Tomography Volume KW - Data Augmentation KW - Deep Learning KW - Deep Neural Network KW - Dice Loss KW - Dice Similarity Coefficient KW - Domain Dataset KW - EEE Keywords Three-dimensional displays KW - Final Ranking KW - Focal Loss KW - Humans KW - image segmentation KW - Imaging KW - Inferior Alveolar Canal KW - Inferior Alveolar Nerve KW - Intersection Over Union KW - Irrigation KW - Mandible KW - Mandibular Canal KW - Medical Experts KW - Mental Foramen KW - Neural Network KW - Panoramic Radiographs KW - Private Dataset KW - Proposals Index Terms Inferior Alveolar KW - Public Datasets KW - semi-supervised learning KW - Sparse Labeling KW - Statistical Shape Model KW - Surgery KW - Teeth KW - Three-Dimensional KW - tooth KW - training KW - Training Data KW - Training Set KW - X-ray imaging N2 - In recent years, several algorithms have been developed for the segmentation of the Inferior Alveolar Canal (IAC) in Cone-Beam Computed Tomography (CBCT) scans. However, the availability of public datasets in this domain is limited, resulting in a lack of comparative evaluation studies on a common benchmark. To address this scientific gap and encourage deep learning research in the field, the ToothFairy challenge was organized within the MICCAI 2023 conference. In this context, a public dataset was released to also serve as a benchmark for future research. The dataset comprises 443 CBCT scans, with voxel-level annotations of the IAC available for 153 of them, making it the largest publicly available dataset of its kind. The participants of the challenge were tasked with developing an algorithm to accurately identify the IAC using the 2D and 3D-annotated scans. This paper presents the details of the challenge and the contributions made by the most promising methods proposed by the participants. It represents the first comprehensive comparative evaluation of IAC segmentation methods on a common benchmark dataset, providing insights into the current state-of-the-art algorithms and outlining future research directions. Furthermore, to ensure reproducibility and promote future developments, an open-source repository that collects the implementations of the best submissions was released. ER -