TY - JOUR ID - Simon-Martinez2020 T1 - {Effects of combining constraint-induced movement therapy and action-observation training on upper limb kinematics in children with unilateral cerebral palsy: a randomized controlled trial} A1 - Simon-Martinez, Cristina A1 - Mailleux, Lisa A1 - Jaspers, Ellen A1 - Ortibus, Els A1 - Desloovere, Kaat A1 - Klingels, Katrijn A1 - Feys, Hilde JA - Scientific Reports Y1 - 2020 VL - 10 IS - 1 SP - 10421 PB - Nature Publishing Group SN - 2045-2322 UR - http://www.nature.com/articles/s41598-020-67427-2 M2 - doi: 10.1038/s41598-020-67427-2 KW - Health care KW - Outcomes research KW - Paediatric research KW - Paediatrics KW - Randomized controlled trials KW - Therapeutics N2 - Modified constraint-induced movement therapy (mCIMT) improves upper limb (UL) motor execution in unilateral cerebral palsy (uCP). As these children also show motor planning deficits, action-observation training (AOT) might be of additional value. Here, we investigated the combined value of AOT to mCIMT on UL kinematics in children with uCP in a randomized controlled trial. Thirty-six children with uCP completed an UL kinematic and clinical evaluation after participating in a 9-day mCIMT camp wearing a splint for 6 h/day. The experimental group (mCIMT   AOT, n = 20) received 15 h of AOT, i.e. video-observation and execution of unimanual tasks. The control group (mCIMT   placebo, n = 16) watched biological-motion free videos and executed the same tasks. We examined changes in motor control (movement duration, peak velocity, time-to-peak velocity, and trajectory straightness) and kinematic movement patterns (using Statistical Parametric Mapping) during the execution of three unimanual, relevant tasks before the intervention, after and at 6 months follow-up. Adding AOT to mCIMT mainly affected movement duration during reaching, whereas little benefit is seen on UL movement patterns. mCIMT, with or without AOT, improved peak velocity and trajectory straightness, and proximal movement patterns. Clinical and kinematic improvements are poorly related. Although there seem to be limited benefits of AOT to CIMT on UL kinematics, our results support the inclusion of kinematics to capture changes in motor control and movement patterns of the proximal joints. M1 - file={:C$\backslash$:/Users/cristina.simonmar/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Simon-Martinez et al. - 2020 - Effects of combining constraint-induced movement therapy and action-observation training on upper limb ki.pdf:pdf} ER -