TY  - JOUR
ID  - Mailleux2017a
T1  - {How does the interaction of presumed timing, location and extent of the underlying brain lesion relate to upper limb function in children with unilateral cerebral palsy?}
A1  - Mailleux, Lisa
A1  - Klingels, Katrijn
A1  - Fiori, Simona
A1  - Simon-Martinez, Cristina
A1  - Demaerel, Philippe
A1  - Locus, Marlies
A1  - Fosseprez, Eva
A1  - Boyd, Roslyn N
A1  - Guzzetta, Andrea
A1  - Ortibus, Els
A1  - Feys, Hilde
JA  - European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society
Y1  - 2017
VL  - 21
IS  - 5
SP  - 763
EP  - 772
PB  - Elsevier Ltd
SN  - 1532-2130
UR  - http://www.ncbi.nlm.nih.gov/pubmed/28606752 http://dx.doi.org/10.1016/j.ejpn.2017.05.006
M2  - doi: 10.1016/j.ejpn.2017.05.006
KW  - Brain injuries
KW  - cerebral palsy
KW  - Magnetic resonance imaging
KW  - Rehabilitation
KW  - Upper extremity
N2  - {BACKGROUND Upper limb (UL) function in children with unilateral cerebral palsy (CP) vary largely depending on presumed timing, location and extent of brain lesions. These factors might exhibit a complex interaction and the combined prognostic value warrants further investigation. This study aimed to map lesion location and extent and assessed whether these differ according to presumed lesion timing and to determine the impact of structural brain damage on UL function within different lesion timing groups. MATERIALS AND METHODS Seventy-three children with unilateral CP (mean age 10 years 2 months) were classified according to lesion timing: malformations (N = 2), periventricular white matter (PWM
M1  - n={29) lesions. neuroanatomical damage was scored using a semi-quantitative mri scale. ul function was assessed at body function and activity level. results cdgm lesions were more pronounced compared to pwm lesions (p = 0.0003). neuroanatomical scores were correlated with a higher degree to ul function in the cdgm group (rs = -0.39 to rs = -0.84) compared to the pwm group (rrb = -0.42 to rs = -0.61). regression analysis found lesion location and extent to explain 75{\%} and 65{\%} (p {\textless} 0.02) respectively
M1  -  of the variance in aha performance in the cdgm group
M1  -  but only 24{\%} and 12{\%} (p {\textless} 0.03) in the pwm group. conclusions in the cdgm group
M1  -  lesion location and extent seems to impact more on ul function compared to the pwm group. in children with pwm lesions
M1  -  other factors like corticospinal tract (re)organization and structural connectivity may play an additional role.}}
M1  - 
file={:C$\backslash$:/Users/cristina.simonmar/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Mailleux et al. - 2017 - How does the interaction of presumed timing
M1  -  location and extent of the underlying brain lesion relate to upper.pdf:pdf}
M1  - 
pmid={28606752}
ER  -